Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 5/20 | 0.50 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007289 | 0.84 | CYP3A4 (0.51) | CDK2LMNAMAPK1CYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL5663856 | 0.83 | PMP22 (0.50) | CDK2LMNAMAPK1CYP3A4MAPT | |
| SCHEMBL5007156 | 0.83 | TTR (0.51) | CDK2LMNAMAPK1CYP3A4MAPT | |
| SCHEMBL10050727 | 0.83 | LMNA (0.46) | LMNAMAPK1CYP3A4MAPTAPEX1 | |
| Hydrochloric Acid SCHEMBL10824889 | 0.81 | TTR (0.50) | CDK2LMNAMAPK1CYP3A4MAPT | |
| SCHEMBL7735396 | 0.79 | CDK2 (0.62) | CDK2CA2CA1CA9LMNA | |
| SCHEMBL10019204 | 0.79 | LMNA (0.42) | LMNAMAPK1CYP3A4MAPTAPEX1 | |
| SCHEMBL9138970 | 0.79 | CDK2 (0.78) | CDK2CA2CA1CA9MAPK1 | |
| SCHEMBL2909360 | 0.76 | CYP3A4 (0.68) | LMNAMAPK1CYP3A4MAPTAPEX1 | |
| SCHEMBL1742387 | 0.76 | CA1 (0.56) | CA2CA1CA9LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6403590-B1 | Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia | ALCON LABORATORIES, INC. | 2002-06-11 | — | — | US | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |
| CN-1275979-A | Isoquinoline compounds useful as urokinase inhibitors | PFIZER (US) | 2000-12-06 | — | — | CN | disclosed |
| EP-1023268-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | Pfizer Limited (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020608-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |