Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 1/20 | 0.62 |
| ▸ | LDHA | P00338 | 1/20 | 0.53 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 5/20 | 0.50 |
| ▸ | CA1 | P00915 | 4/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | ALPG | P10696 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5004409 | 0.84 | TTR (0.53) | CDK2FTOMCL1HSD17B10L3MBTL1 | |
| SCHEMBL21903885 | 0.83 | CDK2 (0.41) | CDK2LDHAFTOMCL1HSD17B10 | |
| SCHEMBL6994641 | 0.79 | CDK2 (0.53) | CDK2LDHAFTOCA2CA1 | |
| SCHEMBL9138970 | 0.79 | CDK2 (0.78) | CDK2LDHAFTOCA2CA1 | |
| SCHEMBL29401806 | 0.77 | CDK2 (1.00) | CDK2LDHAFTOCA2CA1 | |
| SCHEMBL588923 | 0.77 | CDK2 (1.00) | CDK2LDHAFTOCA2CA1 | |
| SCHEMBL7312121 | 0.76 | CDK2 (0.50) | CDK2LDHAFTOCA2CA1 | |
| SCHEMBL2907363 | 0.76 | CYP3A4 (0.60) | MAPK1CYP2C9HSD17B10TDP1MEN1 | |
| SCHEMBL30013323 | 0.76 | CA1 (0.56) | CDK2LDHAFTOCA2CA1 | |
| SCHEMBL30727430 | 0.76 | CA2 (0.59) | CDK2LDHAFTOCA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403590-B1 | Use of certain isoquinolinesulfonyl compounds for the treatment of glaucoma and ocular ischemia | ALCON LABORATORIES, INC. | 2002-06-11 | — | — | US | disclosed |