Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6994156 | 0.82 | DRD2 (0.50) | SLC6A4HTR1ADRD2ADRA1DADRA1A | |
| SCHEMBL6325397 | 0.79 | HTR1A (0.49) | SLC6A4HTR1ADRD2PARP1DRD4 | |
| SCHEMBL6991007 | 0.74 | HTR1A (0.70) | HTR1ADRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL6991545 | 0.73 | DRD2 (0.49) | SLC6A4HTR1ADRD2ADRA1DADRA1A | |
| SCHEMBL6903037 | 0.73 | HTR1A (0.76) | SLC6A4HTR1ADRD2DRD4DRD3 | |
| SCHEMBL8122818 | 0.73 | DRD2 (0.42) | SLC6A4DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL3032145 | 0.73 | DRD2 (0.42) | SLC6A4DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL13222379 | 0.73 | DRD2 (0.42) | SLC6A4HTR1ADRD2ADRA1DADRA1A | |
| SCHEMBL3026960 | 0.73 | DRD2 (0.42) | SLC6A4DRD2ADRA1DADRA1AADRA1B | |
| SCHEMBL13243255 | 0.73 | DRD2 (0.42) | SLC6A4DRD2ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | claimed |
| EP-0932609-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-04 | — | — | EP | claimed |
| WO-1998016530-A1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-e]INDOL-8-ONE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-04-23 | — | — | WO | claimed |
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | disclosed |