Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 12/20 | 0.70 |
| ▸ | DRD2 | P14416 | 10/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.70 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.70 |
| ▸ | HTR2A | P28223 | 4/20 | 0.70 |
| ▸ | DRD3 | P35462 | 3/20 | 0.70 |
| ▸ | DRD4 | P21917 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9386414 | 0.85 | OPRL1 (0.66) | HTR1ADRD2OPRM1OPRK1HTR2A | |
| Spiroxatrine SCHEMBL1255303 | 0.83 | DRD2 (1.00) | HTR1ADRD2OPRM1OPRK1HTR2A | |
| SCHEMBL6908792 | 0.81 | HTR1A (0.73) | HTR1ADRD2OPRM1OPRK1HTR2A | |
| SCHEMBL6908250 | 0.80 | HTR1A (0.69) | HTR1ADRD2OPRM1OPRK1HTR2A | |
| SCHEMBL6776590 | 0.79 | HTR1A (0.67) | HTR1ADRD2OPRM1OPRK1HTR2A | |
| SCHEMBL6906289 | 0.79 | HTR1A (0.71) | HTR1ADRD2OPRM1OPRK1HTR2A | |
| SCHEMBL6994156 | 0.75 | DRD2 (0.50) | HTR1ADRD2HTR2ADRD3DRD4 | |
| SCHEMBL6994776 | 0.74 | SLC6A4 (0.46) | HTR1ADRD2DRD3DRD4ADRA1D | |
| SCHEMBL7998679 | 0.72 | OPRM1 (0.73) | HTR1ADRD2OPRM1OPRK1HTR2A | |
| SCHEMBL8014002 | 0.72 | OPRM1 (0.73) | HTR1ADRD2OPRM1OPRK1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | claimed |
| EP-0932609-B1 | AZAHETEROCYCLYMETHYL DERIVATIVES OF 2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO 2,3-e]INDOL-8-ONE | WYETH CORP (US) | 2003-05-14 | — | — | EP | disclosed |