SCHEMBL6994780

SCHEMBL6994780

CC(c1ccccc1)N(CC(F)(F)F)c1c(-c2c(F)cccc2F)c(Cl)nc2ncnn12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 1/20 0.35
NR1H3 Q13133 1/20 0.35
ENPP1 P22413 6/20 0.34
ALDH1A1 P00352 7/20 0.33
GAA P10253 3/20 0.33
KMT2A Q03164 2/20 0.33
LMNA P02545 2/20 0.33
MEN1 O00255 1/20 0.33
GFER P55789 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
HPGD P15428 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C19 P33261 1/20 0.33
MBOAT4 Q96T53 1/20 0.32
POLB P06746 3/20 0.32
TSHR P16473 2/20 0.32
MAPK1 P28482 2/20 0.32
KDM4E B2RXH2 1/20 0.32
PDE2A O00408 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6999659 0.90 ENPP1 (0.36) ENPP1ALDH1A1GAAKMT2AMEN1
SCHEMBL6997863 0.87 ENPP1 (0.34) ENPP1ALDH1A1GAAKMT2AMEN1
SCHEMBL6997332 0.85 ENPP1 (0.39) ENPP1ALDH1A1KMT2AMBOAT4POLB
SCHEMBL6994525 0.82 ENPP1 (0.36) ENPP1ALDH1A1GAAKMT2AMEN1
SCHEMBL6992972 0.82 ENPP1 (0.39) ENPP1ALDH1A1KMT2AMBOAT4POLB
SCHEMBL6996424 0.82 MBOAT4 (0.38) ENPP1ALDH1A1GAAKMT2AHPGD
SCHEMBL6990567 0.82 ENPP1 (0.34) NR1H2NR1H3ENPP1ALDH1A1GAA
SCHEMBL6993025 0.80 LMNA (0.37) ENPP1ALDH1A1KMT2ALMNAHPGD
SCHEMBL4819577 0.80 ALDH1A1 (0.35) ENPP1ALDH1A1GAAKMT2AMEN1
SCHEMBL6996482 0.77 ENPP1 (0.38) ENPP1ALDH1A1KMT2AMBOAT4POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0975635-B1 FUNGICIDAL TRIFLUOROMETHYLALKYLAMINO-TRIAZOLOPYRIMIDINES BASF AG (DE) 2003-05-07 EP claimed
EP-0975635-B1 FUNGICIDAL TRIFLUOROMETHYLALKYLAMINO-TRIAZOLOPYRIMIDINES BASF AG (DE) 2003-05-07 EP disclosed
EP-0975635-A1 FUNGICIDAL TRIFLUOROMETHYLALKYLAMINO-TRIAZOLOPYRIMIDINES AMERICAN CYANAMID COMPANY (US) 2000-02-02 EP disclosed
WO-1998046608-A1 FUNGICIDAL TRIFLUOROMETHYLALKYLAMINO-TRIAZOLOPYRIMIDINES AMERICAN CYANAMID COMPANY (US) 1998-10-22 WO disclosed