Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 5/20 | 0.36 |
| ▸ | BRAF | P15056 | 4/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997186 | 0.89 | PGR (0.37) | PGRPTGS2HSP90AA1HSP90AB1TDP2 | |
| SCHEMBL7000370 | 0.89 | PTGS2 (0.42) | PGRBRAFPTGS2PTGS1 | |
| SCHEMBL6999726 | 0.88 | HSD11B1 (0.32) | PTGS2PTGS1CYP1A2 | |
| SCHEMBL7001164 | 0.87 | PTGS2 (0.38) | PGRPTGS2PTGS1 | |
| SCHEMBL6997443 | 0.85 | AKR1C3 (0.38) | PGRPTGS1 | |
| SCHEMBL6997590 | 0.84 | PGR (0.43) | PGRPTGS2PTGS1ALDH1A1CYP1A2 | |
| SCHEMBL7001577 | 0.83 | PTGS2 (0.34) | PGRBRAFPTGS2PTGS1ALDH1A1 | |
| SCHEMBL7001563 | 0.83 | PTGS2 (0.34) | PTGS2PTGS1 | |
| SCHEMBL6996644 | 0.83 | PTGS2 (0.40) | PGRBRAFPTGS2PTGS1 | |
| SCHEMBL6995060 | 0.83 | PTGS2 (0.45) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |