Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.52 |
| ▸ | GAK | O14976 | 6/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.48 |
| ▸ | COQ8A | Q8NI60 | 4/20 | 0.48 |
| ▸ | NLK | Q9UBE8 | 4/20 | 0.48 |
| ▸ | SRC | P12931 | 5/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.46 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4455183 | 0.80 | EGFR (0.69) | EGFRSRCERBB2MAP2K1 | |
| SCHEMBL6998602 | 0.76 | MAP2K1 (0.62) | EGFRSRCERBB2MAP2K1 | |
| SCHEMBL6997360 | 0.73 | MAP2K1 (0.64) | EGFRSRCERBB2MAP2K1 | |
| SCHEMBL4448819 | 0.73 | EGFR (0.62) | EGFRSRCERBB2MAP2K1 | |
| SCHEMBL6989870 | 0.72 | EGFR (0.49) | EGFRGAKSRCERBB2MAP2K1 | |
| SCHEMBL19957128 | 0.72 | MET (0.52) | EGFRSRCPDGFRAERBB2MET | |
| SCHEMBL21106121 | 0.71 | EGFR (0.79) | EGFRGAKRIPK2COQ8ANLK | |
| SCHEMBL4450574 | 0.71 | MAP2K1 (0.58) | EGFRSRCERBB2MAP2K1 | |
| SCHEMBL30017094 | 0.69 | FGFR2 (0.61) | EGFRGAKRIPK2COQ8ANLK | |
| SCHEMBL14217352 | 0.68 | EGFR (0.45) | EGFRSRCERBB2METAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | disclosed |
| US-6288082-B1 | COMPOUNDS SUCH AS 6,7-DIETHOXY-4-(INDAN-5-YLAMINO) -QUINOLINE-3-CARBONITRILE USED AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYCSTIC KIDNEY DISEASE | AMERICAN CYANAMID COMPANY | 2001-09-11 | — | — | US | disclosed |
| EP-1117659-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | American Cyanamid Company (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018761-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |