Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 12/20 | 0.51 |
| ▸ | DRD2 | P14416 | 11/20 | 0.51 |
| ▸ | HTR7 | P34969 | 11/20 | 0.51 |
| ▸ | HTR6 | P50406 | 11/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998675 | 0.80 | DRD2 (0.58) | ACHEHTR2ADRD2HTR7HTR6 | |
| SCHEMBL5335431 | 0.79 | ACHE (0.54) | ACHEHTR2ADRD2HTR7HTR6 | |
| SCHEMBL5343113 | 0.75 | ACHE (0.55) | ACHEHTR2ADRD2HTR7HTR6 | |
| SCHEMBL5341884 | 0.74 | ACHE (0.49) | ACHEHTR2ADRD2HTR7HTR6 | |
| SCHEMBL5334930 | 0.73 | ACHE (0.67) | ACHEHTR2ADRD2HTR7HTR6 | |
| SCHEMBL11154995 | 0.73 | ACHE (0.67) | ACHEDRD2 | |
| SCHEMBL10635248 | 0.73 | SIGMAR1 (0.52) | ACHEHTR2ADRD2HTR7HTR6 | |
| Bromide SCHEMBL10892081 | 0.72 | ACHE (0.66) | ACHEDRD2 | |
| SCHEMBL5334026 | 0.71 | ACHE (0.50) | ACHEHTR2ADRD2HTR7HTR6 | |
| SCHEMBL25345725 | 0.71 | DRD2 (0.57) | HTR2ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207677-B1 | ADMINISERING SIGMA RECEPTOR BINDING PIPERIDINE DERIVATIVE FOR TREATING ANXIETY, EPILEPSY, CONVULSION, MOVEMENT DISORDER, AMNESIA | H. LUNDBECK A/S (DK) | 2001-03-27 | — | — | US | claimed |
| EP-0859004-B1 | Piperidine derivatives having anxiolytic effect | LUNDBECK & CO AS H (DK) | 2003-05-02 | — | — | EP | disclosed |
| US-6207677-B1 | ADMINISERING SIGMA RECEPTOR BINDING PIPERIDINE DERIVATIVE FOR TREATING ANXIETY, EPILEPSY, CONVULSION, MOVEMENT DISORDER, AMNESIA | H. LUNDBECK A/S (DK) | 2001-03-27 | — | — | US | disclosed |
| US-6031099-A | Piperidine derivates having anxiolytic effect | H. LUNDBECK A/S (DK) | 2000-02-29 | — | — | US | disclosed |
| EP-0859004-A1 | Piperidine derivatives having anxiolytic effect | H. LUNDBECK A/S (DK) | 1998-08-19 | — | — | EP | disclosed |
| EP-0853085-A1 | Piperidine derivatives having anxiolytic effect | H. LUNDBECK A/S (DK) | 1998-07-15 | — | — | EP | disclosed |
| US-5665725-A | Piperidine derivatives having anxiolytic effect | Lundbeck, H. (DK) | 1997-09-09 | — | — | US | disclosed |
| EP-0593511-A1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | H. LUNDBECK A/S (DK) | 1994-04-27 | — | — | EP | disclosed |
| WO-1992022554-A1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | H. LUNDBECK A/S (DK) | 1992-12-23 | — | — | WO | disclosed |
| EP-0518805-A1 | Piperidine derivatives | H. LUNDBECK A/S (DK) | 1992-12-16 | — | — | EP | disclosed |