Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.37 |
| ▸ | CNR2 | P34972 | 8/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28820301 | 0.84 | P2RX7 (0.49) | P2RX7CNR2PTGER3PTGER2HDAC6 | |
| SCHEMBL7624014 | 0.83 | ESR1 (0.45) | P2RX7CNR2CYP2C19PTGER3PTGER2 | |
| SCHEMBL13285265 | 0.81 | CNR2 (0.51) | P2RX7CNR2KMT2AALDH1A1 | |
| SCHEMBL28530745 | 0.78 | TDP1 (0.52) | CYP2C19CYP1A2CYP3A4KMT2AALDH1A1 | |
| SCHEMBL23360775 | 0.77 | HDAC6 (0.48) | CNR2CYP2C19PTGER3PTGER2CYP2C8 | |
| SCHEMBL6790722 | 0.77 | ITGB3 (0.44) | P2RX7PTGER3PTGER2KMT2A | |
| SCHEMBL2171939 | 0.75 | TDP1 (0.49) | P2RX7CNR2CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL6789700 | 0.75 | PHGDH (0.42) | CNR2CYP2C19PTGER3PTGER2HDAC6 | |
| SCHEMBL28103665 | 0.74 | ALDH1A1 (0.48) | P2RX7CNR2HDAC6KMT2AALDH1A1 | |
| SCHEMBL7123162 | 0.74 | NOTUM (0.46) | P2RX7CNR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345909-A1 | PHENYLACETAMIDO-PYRAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002048114-A1 | PHENYLACETAMIDO- PYRAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA S.P.A. (IT) | 2002-06-20 | — | — | WO | disclosed |