Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CFD | P00746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992420 | 0.78 | TACR1 (0.50) | ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL7433455 | 0.78 | KMT2A (0.59) | LMNASMN1; SMN2ALDH1A1CYP19A1CYP3A4 | |
| SCHEMBL6996129 | 0.77 | ALDH1A1 (0.45) | LMNAALDH1A1SIGMAR1HTTTAAR1 | |
| SCHEMBL19002456 | 0.76 | BLM (0.47) | LMNAALDH1A1RAB9ASIGMAR1KMT2A | |
| SCHEMBL27883950 | 0.73 | RPS6KB1 (0.44) | SMN1; SMN2ALDH1A1RAB9ASIGMAR1NPC1 | |
| SCHEMBL19002453 | 0.73 | PDE10A (0.46) | ALDH1A1CYP2C9KMT2AMEN1PDE10A | |
| SCHEMBL4972856 | 0.72 | POLB (0.46) | ALDH1A1SIGMAR1KMT2AMEN1HTT | |
| SCHEMBL18913833 | 0.72 | POLB (0.46) | ALDH1A1SIGMAR1KMT2AMEN1HTT | |
| SCHEMBL5651092 | 0.72 | POLB (0.46) | ALDH1A1SIGMAR1KMT2AMEN1HTT | |
| SCHEMBL5651099 | 0.72 | POLB (0.46) | ALDH1A1SIGMAR1KMT2AMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823906-B1 | PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORP (US) | 2003-07-09 | — | — | EP | disclosed |
| US-5981520-A | USEFUL FOR TREATING ASTHMA, BRONCHOSPASM, ALLERGIES, ANXIETY, COUGHING OR PAIN | SCHERING CORPORATION (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0823906-A1 | PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996034864-A1 | PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1996-11-07 | — | — | WO | disclosed |