Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18257816 | 0.88 | KMT2A (0.73) | KMT2ASMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL10771524 | 0.87 | KDM4E (0.63) | KMT2APKMSMN1; SMN2MEN1KDM4E | |
| SCHEMBL20327274 | 0.87 | KMT2A (0.76) | KMT2ASMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL8307799 | 0.85 | KMT2A (0.59) | KMT2ASMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL5061283 | 0.82 | TPSAB1 (0.57) | KMT2APKMSMN1; SMN2CYP2C9HSD17B10 | |
| SCHEMBL8609160 | 0.82 | GAA (0.49) | KMT2APKMSMN1; SMN2HTT | |
| SCHEMBL6481645 | 0.79 | PKM (0.82) | PKMSMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL23244269 | 0.78 | GFER (0.64) | KMT2AHTTMEN1KDM4EHSD17B10 | |
| SCHEMBL8608693 | 0.78 | GAA (0.46) | KMT2APKMSMN1; SMN2HTTPOLB | |
| SCHEMBL10287708 | 0.78 | HTT (0.54) | KMT2APKMSMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880512-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1998-12-02 | — | — | EP | disclosed |
| EP-0823906-A1 | PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1998-02-18 | — | — | EP | disclosed |
| WO-1997028141-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1997-08-07 | — | — | WO | disclosed |
| WO-1996034864-A1 | PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1996-11-07 | — | — | WO | disclosed |
| US-5015642-A | Benzothiazinone oxides, processes for their preparation, medicaments containing them and the use thereof, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-05-14 | — | — | US | disclosed |
| EP-0212481-B1 | INDOLINONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOUNDS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-09-12 | — | — | EP | disclosed |
| US-4952598-A | CALCIUM ANTAGONISTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-08-28 | — | — | US | disclosed |
| US-4882329-A | CALCIUM CHANNEL BLOCKERS; CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-21 | — | — | US | disclosed |
| EP-0303180-A1 | Benzothiazinone-oxides, processes for their preparation, medicaments containing them, and their use, as well as intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-15 | — | — | EP | disclosed |
| EP-0244723-A2 | Benzothiazinone derivatives, process for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-11-11 | — | — | EP | disclosed |
| EP-0212481-A1 | Indolinone derivatives, processes for their preparation, pharmaceutical compounds containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |