Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 13/20 | 0.65 |
| ▸ | GABRG2 | P18507 | 13/20 | 0.65 |
| ▸ | GABRB3 | P28472 | 13/20 | 0.65 |
| ▸ | GABRA3 | P34903 | 13/20 | 0.65 |
| ▸ | GABRA2 | P47869 | 12/20 | 0.65 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.65 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.46 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.46 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656307 | 0.86 | GABRA1 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7001889 | 0.86 | GABRA1 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6997776 | 0.85 | GABRA1 (0.61) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2657339 | 0.83 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6995201 | 0.83 | GABRG2 (0.61) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2656654 | 0.83 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6997768 | 0.83 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2658710 | 0.82 | GABRA1 (0.58) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL2656368 | 0.80 | GABRG2 (0.60) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL29550288 | 0.78 | GABRA1 (1.00) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | disclosed |