Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | STK4 | Q13043 | 7/20 | 0.43 |
| ▸ | STK3 | Q13188 | 3/20 | 0.42 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999369 | 0.88 | EGFR (0.58) | EGFRERBB2MAP2K1STK4STK3 | |
| SCHEMBL2204020 | 0.87 | EGFR (0.65) | EGFRERBB2MAP2K1STK4STK3 | |
| SCHEMBL6998421 | 0.82 | EGFR (0.56) | EGFRERBB2MAP2K1STK4STK3 | |
| SCHEMBL2200479 | 0.80 | EGFR (0.67) | EGFRERBB2MAP2K1STK4STK3 | |
| SCHEMBL7001573 | 0.79 | EGFR (0.55) | EGFRERBB2MAP2K1STK4MAP3K8 | |
| SCHEMBL6995272 | 0.77 | MAP2K1 (0.50) | EGFRERBB2MAP2K1STK4STK3 | |
| SCHEMBL6383813 | 0.76 | EGFR (0.65) | EGFRERBB2 | |
| SCHEMBL6382063 | 0.75 | EGFR (0.66) | EGFRERBB2MAP3K8SRC | |
| SCHEMBL6998717 | 0.74 | EGFR (0.45) | EGFRERBB2MAP2K1STK4STK3 | |
| SCHEMBL2203831 | 0.73 | EGFR (1.00) | EGFRERBB2MAP2K1STK4STK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |