Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.56 |
| ▸ | STK4 | Q13043 | 7/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | STK3 | Q13188 | 3/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200289 | 0.87 | EGFR (0.64) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL6999406 | 0.87 | EGFR (0.56) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL6996969 | 0.82 | EGFR (0.57) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL6995272 | 0.80 | MAP2K1 (0.50) | EGFRERBB2STK4STK3MAP2K1 | |
| SCHEMBL2203881 | 0.79 | EGFR (0.65) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL31661626 | 0.79 | EGFR (0.65) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL6383813 | 0.79 | EGFR (0.65) | EGFRERBB2 | |
| SCHEMBL6382063 | 0.78 | EGFR (0.66) | EGFRERBB2SRC | |
| SCHEMBL6998717 | 0.77 | EGFR (0.45) | EGFRERBB2STK4SRCSTK3 | |
| SCHEMBL14855066 | 0.76 | STK4 (0.53) | EGFRERBB2STK4SRCSTK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |