SCHEMBL6995340

SCHEMBL6995340

O=C(Cl)c1ccc(NC(=O)c2ccccc2-c2ccccn2)cc1Br

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALB P02768 1/20 0.49
HTR1A P08908 1/20 0.49
SLC6A2 P23975 1/20 0.49
PDE4A P27815 1/20 0.49
OPRM1 P35372 1/20 0.49
DRD3 P35462 1/20 0.49
HTR2B P41595 1/20 0.49
SLC6A3 Q01959 1/20 0.49
PDE4D Q08499 1/20 0.49
SHH Q15465 1/20 0.49
USP28 Q96RU2 1/20 0.49
SLC29A1 Q99808 1/20 0.49
SMO Q99835 1/20 0.49
ABCG2 Q9UNQ0 1/20 0.49
LMNA P02545 1/20 0.48
GRM4 Q14833 4/20 0.47
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
ALDH1A1 P00352 1/20 0.45
HTT P42858 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6998669 0.89 LMNA (0.52) ALBHTR1ASLC6A2PDE4AOPRM1
SCHEMBL6999075 0.86 GRM4 (0.51) ALBHTR1ASLC6A2PDE4AOPRM1
SCHEMBL6995376 0.83 SMN1; SMN2 (0.56) ALBHTR1ASLC6A2PDE4AOPRM1
SCHEMBL6200210 0.78 CHRNB2 (0.66) LMNAGRM4ALDH1A1HTTCHRNB2
SCHEMBL31447757 0.76 KDM4E (0.46) LMNAGRM4NPC1RAB9AALDH1A1
SCHEMBL3543145 0.76 KDM4E (0.46) LMNAGRM4NPC1RAB9AALDH1A1
SCHEMBL6992682 0.75 HTT (0.55) LMNAGRM4NPC1RAB9AHTT
Hydrochloric Acid SCHEMBL6610315 0.75 KDM4E (0.45) LMNAGRM4NPC1RAB9AALDH1A1
SCHEMBL6993148 0.74 AVPR2 (0.66)
SCHEMBL1017839 0.74 USP28 (0.59) ALBHTR1ASLC6A2PDE4AOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1021444-B1 3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES WYETH CORP (US) 2003-09-24 EP disclosed
EP-1021444-A1 3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-07-26 EP disclosed
EP-0915876-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS American Cyanamid Company (US) 1999-05-19 EP disclosed
US-5880122-A TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER AMERICAN HOME PRODUCTS CORPORATION (US) 1999-03-09 US disclosed
WO-1997049708-A9 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS 1998-05-22 WO disclosed
US-5753648-A THREATING DISEASES CAUSED BY RENAL REABSORPTION OF WATER AMERICAN CYANAMID COMPANY (US) 1998-05-19 US disclosed
WO-1998020011-A1 3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES AMERICAN HOME PRODUCTS CORPORATION (US) 1998-05-14 WO disclosed
WO-1997049708-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1997-12-31 WO disclosed
WO-1997049707-A1 TRICYCLIC BENZAZEPINE VASOPRESSIN ANTAGONISTS AMERICAN CYANAMID COMPANY (US) 1997-12-31 WO disclosed
US-5700796-A USEFUL FOR TREATING CONGESTIVE HEART FAILURE, DISEASE CONDITIONS WITH EXCESS RENAL WATER REABSORPTION AND CONDITIONS WITH INCREASED VASULAR RESISTANCE AND CORONARY VASOCONSTRICTION AMERICAN CYANAMID COMPANY (US) 1997-12-23 US disclosed