Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002298 | 0.92 | PTGS2 (0.46) | PTGS2KMT2APDE3BPDE3APTGS1 | |
| SCHEMBL7006565 | 0.87 | MAPK14 (0.44) | KMT2APDE3BPDE3AMAPK14 | |
| SCHEMBL7010615 | 0.87 | MAPK14 (0.44) | KMT2APDE3BPDE3AMAPK14 | |
| SCHEMBL7008081 | 0.85 | MAPK14 (0.44) | KMT2APDE3BPDE3AMAPK14 | |
| SCHEMBL6485382 | 0.84 | KMT2A (0.50) | PTGS2KMT2APDE3BPDE3APTGS1 | |
| SCHEMBL6483652 | 0.82 | KMT2A (0.50) | PTGS2KMT2APDE3BPDE3APTGS1 | |
| SCHEMBL6999021 | 0.81 | KMT2A (0.48) | KMT2APDE3BPDE3APTGS1ALDH1A1 | |
| SCHEMBL7012237 | 0.80 | RIPK3 (0.45) | KMT2APDE3BPDE3AMAPK14 | |
| SCHEMBL7008536 | 0.80 | RIPK3 (0.45) | KMT2APDE3BPDE3AMAPK14 | |
| SCHEMBL6998740 | 0.78 | PTGS2 (0.48) | PTGS2KMT2APDE3BPDE3APTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246825-B1 | FUSED PYRROLE COMPOUNDS, PHARMACEUTICAL AGENTS CONTAINING THE SAME, AND THE USE THEREOF | MERCKLE GMBH (DE) | 2003-12-17 | — | — | EP | disclosed |