Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK3 | Q9Y572 | 10/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008536 | 1.00 | RIPK3 (0.45) | RIPK3MAPK14KMT2APDE3BPDE3A | |
| SCHEMBL7006189 | 0.97 | RIPK3 (0.44) | RIPK3MAPK14KMT2APDE3BPDE3A | |
| SCHEMBL7006565 | 0.92 | MAPK14 (0.44) | RIPK3MAPK14KMT2APDE3BPDE3A | |
| SCHEMBL7010615 | 0.92 | MAPK14 (0.44) | RIPK3MAPK14KMT2APDE3BPDE3A | |
| SCHEMBL6999021 | 0.90 | KMT2A (0.48) | KMT2APDE3BPDE3A | |
| SCHEMBL7008081 | 0.89 | MAPK14 (0.44) | RIPK3MAPK14KMT2APDE3BPDE3A | |
| SCHEMBL7002298 | 0.87 | PTGS2 (0.46) | MAPK14KMT2APDE3BPDE3A | |
| SCHEMBL6998740 | 0.87 | PTGS2 (0.48) | RIPK3KMT2APDE3BPDE3A | |
| SCHEMBL7007985 | 0.86 | KMT2A (0.52) | RIPK3MAPK14KMT2A | |
| SCHEMBL6291391 | 0.84 | KMT2A (0.51) | RIPK3MAPK14KMT2APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | claimed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | claimed |
| EP-1252163-B1 | 4-PYRIDYL-AND 2,4-PYRIMIDINYL-SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE IN PHARMACY | MERCKLE GMBH (DE) | 2003-09-24 | — | — | EP | disclosed |
| EP-1252163-A2 | 4-PYRIDYL-AND 2,4-PYRIMIDINYL-SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE IN PHARMACY | MERCKLE GMBH (DE) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001057042-A2 | 4-PYRIDYL-AND 2,4-PYRIMIDINYL-SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE IN PHARMACY | MERCKLE GMBH (DE) | 2001-08-09 | — | — | WO | disclosed |