Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | CFTR | P13569 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60709 | 0.87 | ALDH1A1 (0.69) | ALDH1A1HSD17B10CFTRCA1CA2 | |
| SCHEMBL30342070 | 0.87 | ALDH1A1 (0.69) | ALDH1A1HSD17B10CFTRCA1CA2 | |
| SCHEMBL976497 | 0.83 | MMP2 (0.47) | ALDH1A1HSD17B10CFTRKDM4EHPGD | |
| SCHEMBL2730411 | 0.81 | GRM6 (0.49) | ALDH1A1HSD17B10CFTRCA1CA2 | |
| SCHEMBL27651123 | 0.81 | GRM6 (0.42) | ALDH1A1HSD17B10CFTRCA1CA2 | |
| SCHEMBL8892028 | 0.80 | ALDH1A1 (0.59) | ALDH1A1HSD17B10CFTRCA1CA2 | |
| SCHEMBL6542697 | 0.80 | ALDH1A1 (0.46) | ALDH1A1HSD17B10CFTRCA1CA2 | |
| SCHEMBL14589543 | 0.80 | ALDH1A1 (0.59) | ALDH1A1HSD17B10CFTRCA1CA2 | |
| SCHEMBL171563 | 0.80 | ALDH1A1 (0.63) | ALDH1A1HSD17B10CFTRCA1CA2 | |
| SCHEMBL29851692 | 0.80 | ALDH1A1 (0.63) | ALDH1A1HSD17B10CFTRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0980374-B1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PFIZER HOLDING FRANCE (FR) | 2003-02-12 | — | — | EP | disclosed |
| US-6239130-B1 | ASTHMA, ATOPIC DERMATITIS, RHEUMATOID ARTHRITIS, INFLAMMATORY BOWEL DISORDERS, PULMONARY HYPERTENSION, LIVER INJURY, BONE LOSS, SEPTIC SHOCK, OR MULTIPLE SCLEROSIS, | WARNER-LAMBERT COMPANY | 2001-05-29 | — | — | US | disclosed |
| EP-0980374-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998049169-A1 | PHOSPHODIESTERASE 4-INHIBITING DIAZEPINOINDOLONES | PARKE-DAVIS (FR) | 1998-11-05 | — | — | WO | disclosed |