Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 7/20 | 0.51 |
| ▸ | DRD2 | P14416 | 6/20 | 0.51 |
| ▸ | HTR2A | P28223 | 5/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | HTR1B | P28222 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6995726 | 0.88 | HTR1D (0.48) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL6811792 | 0.81 | HTR1D (0.55) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL6812173 | 0.81 | HTR1D (0.55) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL6990054 | 0.79 | HTR6 (0.38) | DRD2DRD4MAPTMEN1KMT2A | |
| SCHEMBL8549578 | 0.78 | HTR1D (0.62) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL8554144 | 0.78 | HTR1D (0.61) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL6630124 | 0.77 | HTR1A (0.38) | HTR1DDRD2HTR1AHTR1BMAPT | |
| SCHEMBL6810878 | 0.71 | MAPT (0.46) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL8549410 | 0.70 | HTR1D (0.84) | HTR1DDRD2HTR2AHTR1ADRD4 | |
| SCHEMBL8553298 | 0.70 | HTR1D (0.84) | HTR1DDRD2HTR2AHTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345930-A2 | PHARMACEUTICAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002050067-A2 | PHARMACEUTICAL HETEROCYCLIC COMPOUNDS | ELI LILLY AND COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |