Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.60 |
| ▸ | SSTR5 | P35346 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876847 | 0.84 | KCNH2 (0.61) | KCNH2NR4A2SSTR5LMNAGAA | |
| SCHEMBL6996422 | 0.81 | KCNH2 (0.62) | KCNH2NR4A2SSTR5LMNAGAA | |
| SCHEMBL7500613 | 0.81 | KCNH2 (0.65) | KCNH2NR4A2SSTR5LMNAALDH1A1 | |
| SCHEMBL7970819 | 0.81 | KDM4E (0.51) | SSTR5LMNAGAAALDH1A1MEN1 | |
| SCHEMBL11265895 | 0.79 | KCNH2 (0.83) | KCNH2NR4A2SSTR5LMNAGAA | |
| SCHEMBL7985049 | 0.79 | KCNH2 (0.65) | KCNH2NR4A2SSTR5MKNK1IRAK4 | |
| SCHEMBL5110805 | 0.79 | KCNH2 (0.65) | KCNH2NR4A2SSTR5LMNAGAA | |
| Bromide SCHEMBL11305424 | 0.78 | KCNH2 (0.81) | KCNH2NR4A2SSTR5LMNAGAA | |
| SCHEMBL7988153 | 0.78 | KCNH2 (0.70) | KCNH2NR4A2SSTR5LMNAGAA | |
| Hydrochloric Acid SCHEMBL9302235 | 0.77 | KCNH2 (0.57) | KCNH2NR4A2SSTR5LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211199-B1 | HISTAMINE AND TACHYKININ RECEPTOR ANTAGONISTS; ANTIASTHMATICS, ANTIEMETICS; RESPIRATORY SYSTEM DISORDERS, INFLAMMATORY BOWEL DISEASE, CONJUNCTIVITIS | AVENTIS PHARMACEUTICALS INC. | 2001-04-03 | — | — | US | disclosed |