Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 13/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 13/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 12/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 11/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997905 | 0.84 | GABRA1 (0.58) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6998714 | 0.82 | GABRG2 (0.48) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7003393 | 0.82 | GABRG2 (0.36) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7001260 | 0.82 | GABRG2 (0.46) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6996450 | 0.81 | GABRG2 (0.67) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7003094 | 0.81 | GABRG2 (0.44) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL6997828 | 0.67 | GABRA1 (0.41) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7005499 | 0.65 | GABRA1 (0.43) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7006121 | 0.65 | GABRG2 (0.65) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7003973 | 0.65 | GABRA1 (0.52) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | disclosed |