Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 19/20 | 0.58 |
| ▸ | GABRG2 | P18507 | 19/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 19/20 | 0.58 |
| ▸ | GABRA3 | P34903 | 19/20 | 0.58 |
| ▸ | GABRA2 | P47869 | 17/20 | 0.58 |
| ▸ | GABRA5 | P31644 | 14/20 | 0.58 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.58 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998714 | 0.91 | GABRG2 (0.48) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7001260 | 0.86 | GABRG2 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6996445 | 0.84 | GABRG2 (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7005499 | 0.82 | GABRA1 (0.43) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6997913 | 0.81 | GABRG2 (0.68) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7006134 | 0.81 | GABRA1 (0.62) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6999458 | 0.79 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7001121 | 0.78 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7421406 | 0.77 | GABRA1 (0.70) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6997828 | 0.75 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | disclosed |