SCHEMBL6996551

SCHEMBL6996551

CCOC(=O)CCCC(=O)c1ccc2c(c1)NC(N)=C(C)O2

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.45
ALOX5 P09917 2/20 0.38
TNF P01375 2/20 0.38
NPC1 O15118 2/20 0.36
MAPT P10636 4/20 0.36
RXFP1 Q9HBX9 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
NPSR1 Q6W5P4 2/20 0.36
PTGS1 P23219 1/20 0.35
PTGS2 P35354 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
CYP1A2 P05177 1/20 0.35
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6999811 0.83 ATM (0.47) ALDH1A1ALOX5MAPTRXFP1SMN1; SMN2
SCHEMBL7002378 0.81 PKM (0.47) ALDH1A1ALOX5MAPTSMN1; SMN2KDM4E
SCHEMBL7001011 0.77 SMYD3 (0.48) ALDH1A1SMN1; SMN2
SCHEMBL7713400 0.76 ALDH1A1 (0.44) ALDH1A1ALOX5NPC1MAPTRXFP1
SCHEMBL6996556 0.70 NPC1 (0.35) ALDH1A1TNFNPC1MAPTSMN1; SMN2
SCHEMBL2743316 0.69 NPC1 (0.57) ALDH1A1NPC1MAPTMEN1RAB9A
SCHEMBL7240961 0.69 TSHR (0.48) ALDH1A1NPC1MAPTSMN1; SMN2KDM4E
SCHEMBL30420736 0.68 SMN1; SMN2 (0.58) ALDH1A1TNFNPC1MAPTSMN1; SMN2
SCHEMBL27568226 0.68 NPC1 (0.51) ALDH1A1NPC1MAPTNPSR1RAB9A
SCHEMBL2743418 0.68 CTNNB1 (0.54) ALDH1A1NPC1MAPTKDM4EKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015437-B1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AG (DE) 2003-12-03 EP disclosed
US-6365736-B1 TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. SCHERING AKTIENGESELLSCHAFT (DE) 2002-04-02 US disclosed
EP-1015437-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 2000-07-05 EP disclosed
WO-1999012915-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed