SCHEMBL7002378

SCHEMBL7002378

CC1=C(N)Nc2cc(C(=O)CCC(=O)O)ccc2O1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.47
TSHR P16473 1/20 0.47
ALDH1A1 P00352 4/20 0.45
KMT2A Q03164 1/20 0.44
ALOX5 P09917 3/20 0.41
CYP1A2 P05177 2/20 0.40
HPGD P15428 1/20 0.40
CYP2C19 P33261 1/20 0.40
HSD17B10 Q99714 1/20 0.40
CTNNB1 P35222 5/20 0.39
WNT3A P56704 4/20 0.39
USP5 P45974 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
NR4A2 P43354 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MAPT P10636 1/20 0.37
FFAR1 O14842 1/20 0.37
LMNA P02545 1/20 0.37
RAB9A P51151 1/20 0.37
HIF1A Q16665 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6999811 0.87 ATM (0.47) PKMALDH1A1ALOX5HPGDL3MBTL1
SCHEMBL6996806 0.84 ALDH1A1 (0.53) PKMALDH1A1KMT2AALOX5HSD17B10
SCHEMBL6996551 0.81 ALDH1A1 (0.45) ALDH1A1KMT2AALOX5CYP1A2SMN1; SMN2
SCHEMBL7348143 0.73 ALDH1A1 (0.64) PKMTSHRALDH1A1KMT2ACYP1A2
SCHEMBL6993989 0.72 SMYD3 (0.53) PKMTSHRALDH1A1KMT2ACYP1A2
SCHEMBL7341640 0.71 ALDH1A1 (0.71) PKMTSHRALDH1A1SMN1; SMN2MAPT
SCHEMBL7713275 0.71 PKM (0.46) PKMTSHRALDH1A1KMT2ACYP1A2
SCHEMBL5670401 0.69 ALDH1A1 (0.39) TSHRALDH1A1KMT2AHPGDHSD17B10
SCHEMBL11352711 0.68 MAPT (0.59) PKMTSHRALDH1A1KMT2ACYP1A2
SCHEMBL10764064 0.68 KMT2A (0.58) PKMTSHRALDH1A1KMT2ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015437-B1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AG (DE) 2003-12-03 EP disclosed
US-6365736-B1 TREATMENT OF NERVOUS SYSTEM DISORDERS, CARDIOVASCULAR DISORDERS AND FOR ACTIVITY AS NO-SYNTHASES (NOS) INHIBITORS. SCHERING AKTIENGESELLSCHAFT (DE) 2002-04-02 US disclosed
EP-1015437-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 2000-07-05 EP disclosed
WO-1999012915-A1 BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND THEIR USE IN PHARMACEUTICALS SCHERING AKTIENGESELLSCHAFT (DE) 1999-03-18 WO disclosed