Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 7/20 | 0.66 |
| ▸ | FOLR1 | P15328 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | NOS1 | P29475 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | ATIC | P31939 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991867 | 0.89 | GART (0.72) | GARTFOLR1NOS1HSD17B10NOS3 | |
| SCHEMBL6993317 | 0.89 | GART (0.72) | GARTFOLR1NOS1HSD17B10NOS3 | |
| SCHEMBL8537889 | 0.80 | GART (0.63) | GARTFOLR1MAPK1ATIC | |
| SCHEMBL7145433 | 0.76 | GART (0.80) | GARTFOLR1ATIC | |
| SCHEMBL22967335 | 0.73 | GART (0.59) | GARTFOLR1KDM4ENOS1ALDH1A1 | |
| SCHEMBL8362067 | 0.73 | GART (0.53) | GARTFOLR1KDM4ENOS1ALDH1A1 | |
| SCHEMBL7812453 | 0.71 | GART (0.69) | GARTFOLR1NOS1ATIC | |
| SCHEMBL6994470 | 0.68 | ALDH1A1 (0.40) | MAPK1KDM4EALDH1A1GAAHPGD | |
| Pelitrexol SCHEMBL13927981 | 0.64 | GART (0.74) | GARTFOLR1ATIC | |
| SCHEMBL6919868 | 0.63 | HDAC3 (0.43) | MAPK1KDM4EALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846111-B1 | SYNTHESES OF OPTICALLY PURE COMPOUNDS USEFUL AS GARFT INHIBITORS AND THEIR INTERMEDIATES | AGOURON PHARMA (US) | 2003-08-27 | — | — | EP | disclosed |
| US-5981748-A | Synthesis of optically pure compounds useful as GARFT inhibitors and their intermediates | AGOURON PHARMACEUTICALS, INC. (US) | 1999-11-09 | — | — | US | disclosed |
| EP-0846111-A1 | SYNTHESES OF OPTICALLY PURE COMPOUNDS USEFUL AS GARFT INHIBITORS AND THEIR INTERMEDIATES | AGOURON PHARMACEUTICALS, INC. (US) | 1998-06-10 | — | — | EP | disclosed |
| WO-1996040674-A1 | SYNTHESES OF OPTICALLY PURE COMPOUNDS USEFUL AS GARFT INHIBITORS AND THEIR INTERMEDIATES | AGOURON PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |