Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 8/20 | 0.47 |
| ▸ | CTSK | P43235 | 7/20 | 0.47 |
| ▸ | CTSB | P07858 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29663697 | 0.91 | ITGB3 (0.52) | ITGB3ITGA2BCTSSCTSKCTSB | |
| SCHEMBL6996970 | 0.87 | ITGB3 (0.64) | ITGB3ITGA2BCTSSCTSKCTSB | |
| SCHEMBL19851257 | 0.87 | ITGB3 (0.64) | ITGB3ITGA2BCTSSCTSKCTSB | |
| SCHEMBL20437145 | 0.86 | ITGB3 (0.52) | ITGB3ITGA2BCTSSCTSKCTSB | |
| SCHEMBL22193729 | 0.85 | CTSS (0.53) | ITGB3ITGA2BCTSSCTSKCTSB | |
| SCHEMBL20415878 | 0.85 | PPARG (0.54) | ITGB3ITGA2BCTSSCTSKCTSB | |
| SCHEMBL28736964 | 0.82 | ITGB3 (0.47) | ITGB3ITGA2BCTSSCTSKCTSB | |
| SCHEMBL28736965 | 0.82 | ITGB3 (0.47) | ITGB3ITGA2BCTSSCTSKCTSB | |
| SCHEMBL19493093 | 0.82 | CTSS (0.51) | ITGB3ITGA2BCTSSCTSKCTSB | |
| SCHEMBL6473855 | 0.81 | CTSS (0.64) | CTSSCTSKCTSBCTSLACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183383-B2 | Protein tyrosine phosphatase 1B inhibitor, preparation methods and uses thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2012-05-22 | — | — | US | disclosed |
| US-20100197927-A1 | Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (JP) | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197927-A1 | Protein Tyrosine Phosphatase 1B Inhibitor, Preparation Methods and Uses Thereof | PTPA, PTPN7, PTPN5 | ITGB3 4715/4885ITGA2B 3983/4885CTSS 3659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.