Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.64 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.64 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.55 |
| ▸ | CTSS | P25774 | 6/20 | 0.52 |
| ▸ | CTSK | P43235 | 5/20 | 0.52 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.51 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.47 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996970 | 1.00 | ITGB3 (0.64) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL20437145 | 0.89 | ITGB3 (0.52) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL29663697 | 0.89 | ITGB3 (0.52) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL22193729 | 0.88 | CTSS (0.53) | ITGB3ITGA2BPTPN1CTSSCTSK | |
| SCHEMBL6996966 | 0.87 | ITGB3 (0.50) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL14601773 | 0.86 | ITGB3 (0.55) | ITGB3ITGA2BACEPPARG | |
| SCHEMBL28736965 | 0.85 | ITGB3 (0.47) | ITGB3ITGA2BPTPN1CTSSCTSK | |
| SCHEMBL28736964 | 0.85 | ITGB3 (0.47) | ITGB3ITGA2BPTPN1CTSSCTSK | |
| SCHEMBL2780406 | 0.85 | ACE (0.55) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL31344368 | 0.85 | ACE (0.55) | ITGB3ITGA2BACEPTPN1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108456194-B | Triazole antibacterial derivative, and pharmaceutical composition and application thereof | 武汉朗来科技发展有限公司 | 2021-06-22 | — | — | CN | disclosed |
| US-11040958-B2 | Triazole antimicrobial derivative, pharmaceutical composition and use thereof | WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2021-06-22 | — | — | US | disclosed |
| US-10954236-B2 | Tyrosine amide derivatives as Rho-Kinase inhibitors | CHIESI FARMACEUTICI S.P.A. (IT) | 2021-03-23 | — | — | US | disclosed |
| EP-3573987-B1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARM SPA (IT) | 2021-03-10 | — | — | EP | disclosed |
| CN-107033186-B | Posaconazole derivatives, pharmaceutical compositions and uses thereof | 武汉朗来科技发展有限公司 | 2020-06-09 | — | — | CN | disclosed |
| US-20200079774-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2020-03-12 | — | — | US | disclosed |
| US-10238623-B2 | C14-hydroxyl esterified amino acid derivative of triptolide, and preparation method and use thereof | HANGZHOU WEBEN PHARMACEUTICALS INC (CN) | 2019-03-26 | — | — | US | disclosed |
| US-20190038621-A1 | POSACONAZOLE DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF | WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) | 2019-02-07 | — | — | US | disclosed |
| US-20180215758-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2018-08-02 | — | — | US | disclosed |
| US-20180036277-A1 | C14-HYDROXYL ESTERIFIED AMINO ACID DERIVATIVE OF TRIPTOLIDE, AND PREPARATION METHOD AND USE THEREOF | HANGZHOU WEBEN PHARMACEUTICALS INC (CN) | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180036277-A1 | C14-HYDROXYL ESTERIFIED AMINO ACID DERIVATIVE OF TRIPTOLIDE, AND PREPARATION METHOD AND USE THEREOF | MYC, MYCBP, MYCBP2 | ITGB3 4741/4885ITGA2B 3359/4885ACE 3227/4885 |
| US-20190038621-A1 | POSACONAZOLE DERIVATIVE, PHARMACEUTICAL COMPOSITION AND USE THEREOF | CYP3A43, ERG28, SORD | ITGB3 705/4885ITGA2B 2161/4885ACE 1608/4885 |
| US-10954236-B2 | Tyrosine amide derivatives as Rho-Kinase inhibitors | ROCK1, ROCK2, CIT | ITGB3 2624/4885ITGA2B 2602/4885ACE 1109/4885 |
| US-20200079774-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | ROCK1, ROCK2, CIT | ITGB3 2624/4885ITGA2B 2602/4885ACE 1109/4885 |
| US-10238623-B2 | C14-hydroxyl esterified amino acid derivative of triptolide, and preparation method and use thereof | MYC, MYCBP, MYCBP2 | ITGB3 4741/4885ITGA2B 3359/4885ACE 3227/4885 |
| US-11040958-B2 | Triazole antimicrobial derivative, pharmaceutical composition and use thereof | SLCO1B3, CYP3A43, GSK3B | ITGB3 526/4885ITGA2B 3255/4885ACE 1385/4885 |
| US-20180215758-A1 | TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS | ROCK1, ROCK2, CIT | ITGB3 2624/4885ITGA2B 2602/4885ACE 1109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.