Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.54 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.48 |
| ▸ | RET | P07949 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31613810 | 0.76 | EGFR (0.50) | HTR2AHTR2CHRH1EGFRHDAC4 | |
| SCHEMBL5667766 | 0.76 | EGFR (0.50) | HTR2AHTR2CHRH1EGFRHDAC4 | |
| SCHEMBL17187194 | 0.76 | HDAC4 (0.48) | HTR2AHTR2CHRH1RETEGFR | |
| SCHEMBL3797401 | 0.75 | HDAC4 (0.52) | HTR2AHTR2CHRH1RETEGFR | |
| SCHEMBL13489152 | 0.75 | EGFR (0.49) | HTR2AHTR2CHRH1EGFRHDAC4 | |
| SCHEMBL16822181 | 0.74 | ALDH1A1 (0.47) | HTR2AHRH1EGFRHDAC4HDAC7 | |
| Hydrochloric Acid SCHEMBL16822115 | 0.73 | MEN1 (0.47) | HTR2AHRH1EGFRHDAC4HDAC7 | |
| SCHEMBL1105797 | 0.73 | HDAC4 (0.50) | HTR2AHTR2CHRH1RETEGFR | |
| SCHEMBL15314698 | 0.73 | HDAC4 (0.50) | HTR2AHTR2CHRH1RETEGFR | |
| SCHEMBL20094217 | 0.73 | HDAC4 (0.55) | HTR2AHTR2CHRH1RETEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069132-B1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | SERVIER LAB (FR) | 2003-10-01 | — | — | EP | disclosed |
| US-6277851-B1 | ORALLY ADMINISTERED TRYPSIN-RELATED SERINE PROTEASE INHIBITORS; ANTICOAGULANTS | ADIR ET COMPAGNIE (FR) | 2001-08-21 | — | — | US | disclosed |
| EP-1069132-A1 | Bicyclic derivatives of amino-pyrazinones, process of preparation and pharmaceutical compositions comprising them | ADIR ET COMPAGNIE (FR) | 2001-01-17 | — | — | EP | disclosed |