Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 6/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | UGCG | Q16739 | 4/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7004056 | 0.76 | SLC6A3 (0.78) | SLC6A3SLC6A2SLC6A4LMNAKMT2A | |
| SCHEMBL6997259 | 0.72 | SLC6A3 (1.00) | SLC6A3SLC6A2SLC6A4LMNAKMT2A | |
| SCHEMBL6998367 | 0.68 | SLC6A3 (1.00) | SLC6A3SLC6A2SLC6A4LMNAKMT2A | |
| SCHEMBL3111862 | 0.67 | SLC6A3 (0.50) | SLC6A3SLC6A2SLC6A4LMNAMAPT | |
| SCHEMBL6041278 | 0.67 | KMT2A (0.59) | SLC6A3LMNAKMT2AALDH1A1MAPT | |
| SCHEMBL1348375 | 0.67 | SLC6A3 (0.49) | SLC6A3LMNAMAPTTP53HTT | |
| SCHEMBL6043390 | 0.64 | KMT2A (0.55) | SLC6A3LMNAKMT2AALDH1A1MAPT | |
| SCHEMBL1350533 | 0.63 | NPSR1 (0.47) | SLC6A3LMNATP53HTTGRIN2B | |
| SCHEMBL6999803 | 0.63 | SLC6A3 (1.00) | SLC6A3LMNAKMT2AALDH1A1MAPT | |
| SCHEMBL3444521 | 0.62 | SLC6A3 (0.47) | SLC6A3SLC6A2SLC6A4ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242080-A4 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | UNIV GEORGETOWN (US) | 2003-01-22 | — | — | EP | claimed |
| EP-1242080-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2002-09-25 | — | — | EP | claimed |
| WO-2001022964-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2001-04-05 | — | — | WO | claimed |
| EP-1242080-A4 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | UNIV GEORGETOWN (US) | 2003-01-22 | — | — | EP | disclosed |
| EP-1242080-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001022964-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2001-04-05 | — | — | WO | disclosed |