Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | UGCG | Q16739 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997259 | 0.88 | SLC6A3 (1.00) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL7001403 | 0.78 | SLC6A3 (0.78) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL6997648 | 0.76 | SLC6A3 (1.00) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL6999061 | 0.72 | SLC6A3 (0.68) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL3111862 | 0.71 | SLC6A3 (0.50) | SLC6A3MAPTLMNASLC6A2SLC6A4 | |
| SCHEMBL6997233 | 0.70 | KMT2A (1.00) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL7001994 | 0.68 | KMT2A (0.68) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL18390054 | 0.67 | UGCG (0.59) | SLC6A3KMT2AALDH1A1LMNACYP3A4 | |
| SCHEMBL4194116 | 0.67 | SLC6A3 (1.00) | SLC6A3KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL3444521 | 0.65 | SLC6A3 (0.47) | SLC6A3ALDH1A1SLC6A2SLC6A4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242080-A4 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | UNIV GEORGETOWN (US) | 2003-01-22 | — | — | EP | claimed |
| EP-1242080-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2002-09-25 | — | — | EP | claimed |
| WO-2001022964-A1 | DOPAMINE TRANSPORTER INHIBITORS AND THEIR USE | GEORGETOWN UNIVERSITY (US) | 2001-04-05 | — | — | WO | claimed |