Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.50 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL6728314 | 0.97 | NAPRT (0.61) | NAPRTKMT2AMEN1CPT1BALDH1A1 | |
| SCHEMBL2783342 | 0.86 | NAPRT (0.65) | NAPRTKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL3074392 | 0.82 | KMT2A (0.74) | NAPRTKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL7611819 | 0.80 | CPT1B (0.78) | CPT1BCES2CES1TP53 | |
| SCHEMBL7991738 | 0.78 | NAPRT (0.50) | NAPRTKMT2AMEN1ALDH1A1CYP1A2 | |
| SCHEMBL7991741 | 0.78 | NAPRT (0.50) | NAPRTKMT2AMEN1ALDH1A1CYP1A2 | |
| Isonicotinic Acid SCHEMBL1108 | 0.78 | — | — | |
| Isonicotinic Acid SCHEMBL1414914 | 0.78 | NAPRT (1.00) | NAPRTKMT2AMEN1ALDH1A1CYP1A2 | |
| Hydrochloric Acid SCHEMBL29249310 | 0.77 | CPT1B (0.74) | CPT1BCES2CES1TP53 | |
| SCHEMBL9671846 | 0.77 | NAPRT (0.54) | NAPRTKMT2AMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170296681-A1 | COMPOSITIONS AND METHODS FOR IMAGING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2017-10-19 | — | — | US | disclosed |
| US-20130209360-A1 | Compositions and Methods for Imaging | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-08-15 | — | — | US | disclosed |
| EP-1021448-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6130229-A | Tricyclic compounds having activity as RAS-FPT inhibitors | SCHERING CORPORATION (US) | 2000-10-10 | — | — | US | disclosed |
| EP-1021448-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998015556-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORPORATION (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0173497-B1 | TETRACYCLIC SPIRO-HYDANTOIN ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1989-09-06 | — | — | EP | disclosed |
| US-4656169-A | ENZYME INHIBITORS | PFIZER INC. (US) | 1987-04-07 | — | — | US | disclosed |
| WO-1986001107-A1 | TETRACYCLIC SPIRO-HYDANTOIN ALDOSE REDUCTASE INHIBITORS, COMPOSITIONS AND METHODS OF MAKING | PFIZER INC. (US) | 1986-02-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170296681-A1 | COMPOSITIONS AND METHODS FOR IMAGING | GPX4, PRDX5, PRDX2 | NAPRT 3098/4885KMT2A 4652/4885MEN1 1217/4885 |
| US-20130209360-A1 | Compositions and Methods for Imaging | GPX4, PRDX5, PRDX2 | NAPRT 3098/4885KMT2A 4652/4885MEN1 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.