Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PDE9A | O76083 | 1/20 | 0.49 |
| ▸ | MAP2 | P11137 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PADI4 | Q9UM07 | 7/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | DDO | Q99489 | 1/20 | 0.44 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.44 |
| ▸ | IDE | P14735 | 1/20 | 0.44 |
| ▸ | MPI | P34949 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998517 | 0.83 | MAPT (0.51) | MAPTKDM4EALDH1A1HPGDPDE9A | |
| SCHEMBL6991657 | 0.82 | ALDH1A1 (0.53) | MAPTKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL10648743 | 0.81 | MAPT (0.59) | MAPTKDM4EALDH1A1HPGDPDE9A | |
| SCHEMBL28132803 | 0.77 | MAPT (0.71) | MAPTKDM4EALDH1A1HPGDPDE9A | |
| SCHEMBL3743399 | 0.76 | KDM4E (0.70) | MAPTKDM4EALDH1A1HPGDPDE9A | |
| SCHEMBL4455323 | 0.76 | MAPT (1.00) | MAPTKDM4EALDH1A1PDE9ADAO | |
| SCHEMBL378030 | 0.76 | MAPT (0.65) | MAPTKDM4EALDH1A1HPGDPDE9A | |
| SCHEMBL6825380 | 0.76 | MAPT (0.65) | MAPTKDM4EALDH1A1HPGDPDE9A | |
| SCHEMBL6995868 | 0.74 | KDM4E (0.64) | MAPTKDM4EALDH1A1HPGDMAP2 | |
| SCHEMBL7811680 | 0.73 | KDM4E (0.70) | MAPTKDM4EALDH1A1HPGDPDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003724-B1 | SUBSTITUTED QUINOLINE DERIVATIVES WITH ANTIVIRAL ACTION | AVENTIS PHARMA GMBH (DE) | 2003-02-12 | — | — | EP | disclosed |
| EP-1003724-A1 | SUBSTITUTED QUINOLINE DERIVATIVES WITH ANTIVIRAL ACTION | Aventis Pharma Deutschland GmbH (DE) | 2000-05-31 | — | — | EP | disclosed |
| WO-1997037977-A1 | SUBSTITUTED QUINOLINE DERIVATIVES WITH ANTIVIRAL ACTION | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-10-16 | — | — | WO | disclosed |