Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6051959 | 0.80 | PDE2A (0.63) | PDE2AKMT2AKDM4E | |
| SCHEMBL6993028 | 0.79 | PDE2A (0.47) | PDE2ACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7503850 | 0.78 | PDE2A (0.42) | PDE2ACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL2831825 | 0.77 | PDE2A (0.46) | PDE2AKMT2A | |
| SCHEMBL6992823 | 0.77 | PDE9A (0.53) | PDE2AKMT2A | |
| SCHEMBL6987648 | 0.76 | PDE2A (0.47) | PDE2ACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7438629 | 0.76 | PDE2A (0.44) | PDE2ACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7499444 | 0.75 | PDE2A (0.40) | PDE2ACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL7436563 | 0.75 | PDE2A (0.57) | PDE2ACCNE2CDK4CCND1CCNE1 | |
| SCHEMBL6051965 | 0.75 | PDE2A (0.57) | PDE2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973774-B1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2003-01-22 | — | — | EP | disclosed |
| US-6174884-B1 | CARDIOVASCULAR DISORDERS; CEREBROVASCULAR DISEASES; VASCULAR SYSTEM DISORDERS, ESPECIALLY THE PERIPHERAL BLOOD VESSELS; UROGENITAL DISORDERS; HYPOTENSIVE AGENTS; ANTIARRYTHMIA AND -ISCHEMIC AGENTS; PHOSPHODIESTERASE ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 2001-01-16 | — | — | US | disclosed |