Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.57 |
| ▸ | RNASEH1 | O60930 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6051959 | 0.94 | PDE2A (0.63) | PDE2ARNASEH1ADORA3KMT2A | |
| SCHEMBL6051965 | 0.91 | PDE2A (0.57) | PDE2AADORA3KMT2A | |
| SCHEMBL7442300 | 0.91 | PDE2A (0.57) | PDE2AADORA3CCNE2CCNE1CDK2 | |
| SCHEMBL7436632 | 0.87 | PDE2A (0.53) | PDE2AADORA3CCNB2CCNE2CDK1 | |
| SCHEMBL6052132 | 0.85 | PDE2A (0.51) | PDE2AADORA3CCNE2CCNE1CDK2 | |
| SCHEMBL6051979 | 0.84 | PDE2A (0.53) | PDE2AADORA3CCNB2CCNE2CDK1 | |
| SCHEMBL7443572 | 0.83 | PDE2A (0.66) | PDE2ARNASEH1ADORA3CCNB2CDK1 | |
| SCHEMBL7440929 | 0.83 | PDE2A (0.54) | PDE2ARNASEH1CCNE2CCNE1CDK2 | |
| SCHEMBL7442320 | 0.81 | PDE2A (0.52) | PDE2ARNASEH1ADORA3CCNE2CCNE1 | |
| SCHEMBL7435951 | 0.80 | PDE2A (0.46) | PDE2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5861396-A | CARDIOVASCULAR DISORDERS AND UROGENITAL SYSTEMS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-19 | — | — | US | disclosed |
| EP-0771799-A1 | Purin-6-one derivatives | BAYER AG (DE) | 1997-05-07 | — | — | EP | disclosed |