Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997571 | 0.86 | ALDH1A1 (0.38) | FAAHALDH1A1GAACYP19A1XDH | |
| SCHEMBL7885859 | 0.80 | RIPK2 (0.43) | FAAHALDH1A1GAAKMT2AKDM4E | |
| SCHEMBL6997387 | 0.79 | TSHR (0.50) | FAAHALDH1A1GAAKMT2AMAPT | |
| SCHEMBL6999349 | 0.77 | KDR (0.39) | FAAHALDH1A1GAACYP19A1TSHR | |
| SCHEMBL6992446 | 0.77 | LMNA (0.38) | FAAHLMNA | |
| SCHEMBL6997684 | 0.76 | TSHR (0.37) | FAAHGAATSHR | |
| SCHEMBL7409812 | 0.74 | PDE2A (0.36) | GAA | |
| SCHEMBL4759855 | 0.71 | KDM4E (0.41) | ALDH1A1XDHKMT2AFNTAFNTB | |
| SCHEMBL7355527 | 0.70 | MEN1 (0.43) | FAAHKMT2ALMNATSHR | |
| SCHEMBL7885863 | 0.70 | MEN1 (0.42) | FAAHKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1151155-C | 1, 5-dihydro-pyrazolo [3, 4-D ] -pyrimidone derivatives | — | 2004-05-26 | — | — | CN | disclosed |
| EP-0973774-B1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2003-01-22 | — | — | EP | disclosed |
| US-6174884-B1 | CARDIOVASCULAR DISORDERS; CEREBROVASCULAR DISEASES; VASCULAR SYSTEM DISORDERS, ESPECIALLY THE PERIPHERAL BLOOD VESSELS; UROGENITAL DISORDERS; HYPOTENSIVE AGENTS; ANTIARRYTHMIA AND -ISCHEMIC AGENTS; PHOSPHODIESTERASE ACTIVITY | BAYER AKTIENGESELLSCHAFT (DE) | 2001-01-16 | — | — | US | disclosed |
| CN-1255133-A | 1,5-dihydro-pyrazolo [3,4-D]-pyrimidinone derivatives | BAYER AG (DE) | 2000-05-31 | — | — | CN | disclosed |
| EP-0973774-A1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040384-A1 | 1,5-DIHYDRO-PYRAZOLO[3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-17 | — | — | WO | disclosed |