Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996007 | 0.88 | PDE4A (0.41) | LMNALPAR1PDE4APDE4BPDE4C | |
| SCHEMBL7885859 | 0.84 | RIPK2 (0.43) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7510987 | 0.82 | LMNA (0.39) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7381725 | 0.80 | PDE4A (0.39) | LPAR1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6995428 | 0.80 | DRD2 (0.38) | LMNALPAR1PDE4APDE4BPDE4C | |
| SCHEMBL6993975 | 0.78 | LMNA (0.36) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6998949 | 0.77 | FAAH (0.38) | LMNAFAAH | |
| SCHEMBL7851968 | 0.76 | DAGLA (0.37) | PDE4APDE4BPDE4CPDE4DGRIK1 | |
| SCHEMBL7355527 | 0.75 | MEN1 (0.43) | LMNAPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7885863 | 0.74 | MEN1 (0.42) | LPAR1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973774-B1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2003-01-22 | — | — | EP | disclosed |
| EP-0973774-A1 | 1,5-DIHYDRO-PYRAZOLO 3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040384-A1 | 1,5-DIHYDRO-PYRAZOLO[3,4-D]-PYRIMIDINONE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 1998-09-17 | — | — | WO | disclosed |