Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 10/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998916 | 0.81 | MEN1 (0.46) | MEN1KMT2ACSNK2A2CSNK2A1TUBB4A | |
| SCHEMBL19035598 | 0.77 | CHRNB2 (0.61) | MEN1KMT2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6215755 | 0.76 | CYP3A4 (0.45) | MEN1KMT2ARECQLKDM4EHSD17B10 | |
| SCHEMBL29575346 | 0.75 | IGF1R (0.48) | RECQLNR3C2 | |
| SCHEMBL1940483 | 0.75 | IGF1R (0.48) | RECQLNR3C2 | |
| SCHEMBL5913167 | 0.75 | NR3C2 (0.53) | MEN1KMT2ARECQLNR3C2 | |
| SCHEMBL2464156 | 0.74 | MEN1 (0.49) | MEN1KMT2ACSNK2A2CSNK2A1RECQL | |
| SCHEMBL17919172 | 0.74 | MEN1 (0.49) | MEN1KMT2ACSNK2A2CSNK2A1TUBB4A | |
| SCHEMBL501285 | 0.73 | L3MBTL1 (0.52) | RECQLNR3C2TYK2 | |
| SCHEMBL29507273 | 0.73 | L3MBTL1 (0.52) | RECQLNR3C2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531466-B2 | E.g., a 1-aza-10-(1-hydroxyethyl-11-oxo-4-(het-methylene)-tricyclo(7.2 .0.0(3,8))undec-2-ene-2-carboxylate; good activity against grampositive bacteria such as methicillin-resistant Staphylococcus aureus and epidermidis | GLAXOSMITHKLINE SPA (IT) | 2003-03-11 | — | — | US | disclosed |
| EP-0937078-B1 | TRICYCLIC CARBAPENEM COMPOUNDS | GLAXOSMITHKLINE SPA (IT) | 2003-02-12 | — | — | EP | disclosed |
| US-20010047094-A1 | Tricyclic carbapenem compounds | GLAXO WELLCOME SPA | 2001-11-29 | — | — | US | disclosed |
| EP-0937078-A1 | TRICYCLIC CARBAPENEM COMPOUNDS | GLAXO WELLCOME S.p.A. (IT) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998021210-A1 | TRICYCLIC CARBAPENEM COMPOUNDS | GLAXO WELLCOME S.P.A. (IT) | 1998-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010047094-A1 | Tricyclic carbapenem compounds | OXA1L, GNE, MGAM | MEN1 2910/4885KMT2A 1665/4885CSNK2A2 758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.