Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.49 |
| ▸ | CA1 | P00915 | 5/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.46 |
| ▸ | CA9 | Q16790 | 5/20 | 0.45 |
| ▸ | CA12 | O43570 | 4/20 | 0.45 |
| ▸ | CCNC | P24863 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.40 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002356 | 0.88 | PTGS2 (0.51) | PTGS2 | |
| SCHEMBL6999688 | 0.88 | PTGS2 (0.60) | CA2CA1PTGS2CA9CA12 | |
| SCHEMBL7002002 | 0.86 | PTGS2 (0.56) | CA2CA1PTGS2CA9CA12 | |
| SCHEMBL6998878 | 0.85 | PTGS2 (0.57) | CA2CA1PTGS2CA9CA12 | |
| SCHEMBL7000106 | 0.85 | CA2 (0.53) | CA2CA1PTGS2CA9CA12 | |
| SCHEMBL7003386 | 0.85 | CA2 (0.49) | CA2CA1PTGS2CA9CA12 | |
| SCHEMBL6992672 | 0.85 | PTGS2 (0.51) | PTGS2 | |
| SCHEMBL6994786 | 0.85 | CA2 (0.45) | CA2CA1PTGS2CA9CA12 | |
| SCHEMBL7001899 | 0.85 | CA2 (0.57) | CA2CA1PTGS2CA9CA12 | |
| SCHEMBL15000221 | 0.83 | RAB9A (0.40) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |