Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 4/20 | 0.46 |
| ▸ | PLG | P00747 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6437497 | 0.80 | PLAU (0.63) | DYRK1APLAUPLGMAP4K4DYRK1B | |
| SCHEMBL6436982 | 0.79 | PLAU (0.47) | DYRK1APLAUPLGCDK2CCNT1 | |
| SCHEMBL7000177 | 0.75 | PLAU (0.80) | DYRK1APLAUPLG | |
| SCHEMBL11845968 | 0.72 | PLAU (0.55) | PLAU | |
| SCHEMBL6433004 | 0.70 | PLAU (0.65) | PLAUPLGMAP4K4RAF1BRAF | |
| SCHEMBL6435471 | 0.70 | FDPS (0.50) | PLAUPLGFDPS | |
| SCHEMBL6436143 | 0.69 | PLAU (0.59) | PLAUPLGBRAF | |
| SCHEMBL6440591 | 0.69 | PLAU (0.50) | PLAUMAP4K4RAF1BRAFHDAC2 | |
| SCHEMBL13738498 | 0.68 | HDAC3 (0.38) | PLAUPLGHDAC6 | |
| Hydrochloric Acid SCHEMBL6991115 | 0.68 | PLAU (0.58) | PLAUPLGBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |