Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 17/20 | 0.80 |
| ▸ | PLG | P00747 | 9/20 | 0.71 |
| ▸ | PLAT | P00750 | 5/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ATP4A | P20648 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ATP4B | P51164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6437504 | 0.78 | PLAU (1.00) | PLAUPLGPLAT | |
| SCHEMBL6436984 | 0.78 | PLAU (0.73) | PLAUPLGPLAT | |
| SCHEMBL7000174 | 0.75 | DYRK1A (0.47) | PLAUPLGDYRK1A | |
| SCHEMBL6440595 | 0.68 | PLAU (0.75) | PLAUPLGPLATATP4AATP4B | |
| SCHEMBL6433009 | 0.68 | PLAU (1.00) | PLAUPLGPLATATP4AATP4B | |
| SCHEMBL13251161 | 0.67 | MAP4K4 (0.46) | PLAUPLGDYRK1ANPC1RAB9A | |
| SCHEMBL28147639 | 0.67 | HSD17B1 (0.68) | DYRK1ANPC1RAB9A | |
| SCHEMBL20733139 | 0.66 | MAP4K4 (0.56) | DYRK1ANPC1RAB9A | |
| SCHEMBL24573026 | 0.65 | DYRK1A (0.60) | DYRK1AMAPT | |
| SCHEMBL22120045 | 0.65 | LMNA (0.79) | DYRK1ANPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023268-B1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LTD (GB) | 2003-05-21 | — | — | EP | disclosed |
| US-6248738-B1 | ANTIULCER AGENTS, ANGIOGENESIS INHIBITORS, ANTIMETASTASIS AGENTS, ANTITUMOR AGENTS | PFIZER INC. | 2001-06-19 | — | — | US | disclosed |
| EP-1023268-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | Pfizer Limited (GB) | 2000-08-02 | — | — | EP | disclosed |
| WO-1999020608-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |