Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PTPRC | P08575 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TDP2 | O95551 | 2/20 | 0.47 |
| ▸ | NSD2 | O96028 | 2/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4052223 | 0.81 | APP (0.50) | MAPTSMN1; SMN2TDP1GAAALDH1A1 | |
| SCHEMBL4050960 | 0.81 | MAPT (0.63) | MAOBMAPTSMN1; SMN2KMT2ATDP2 | |
| SCHEMBL6998860 | 0.81 | FNTA (0.49) | MAOBKMT2AMEN1MAOA | |
| SCHEMBL11635162 | 0.80 | MAOB (0.47) | MAOBMAPTATMSMN1; SMN2TSHR | |
| SCHEMBL2197988 | 0.79 | MAPK14 (0.58) | MAOBMAPTATMSMN1; SMN2PKM | |
| SCHEMBL4060672 | 0.78 | ALDH1A1 (0.66) | MAOBMAPTSMN1; SMN2KMT2ATDP1 | |
| SCHEMBL1728678 | 0.77 | MAOA (0.47) | MAOBMAPTPTPRCCTSLCTSS | |
| SCHEMBL29375440 | 0.77 | MAPT (0.67) | MAOBMAPTSMN1; SMN2PKMTSHR | |
| SCHEMBL86392 | 0.77 | MAPT (0.67) | MAOBMAPTSMN1; SMN2PKMTSHR | |
| SCHEMBL7255792 | 0.76 | CES1 (0.61) | PKMPTPRCCTSLCTSSPTPN13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021448-B1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORP (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-1021448-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998015556-A1 | TRICYCLIC COMPOUNDS HAVING ACTIVITY AS Ras-FPT INHIBITORS | SCHERING CORPORATION (US) | 1998-04-16 | — | — | WO | disclosed |