SCHEMBL7001330

SCHEMBL7001330

C=CC[C@](N)(Cc1ccccc1)C(=O)OC(=O)OC(C)(C)C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.42
ALDH1A1 P00352 4/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
HIF1A Q16665 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
SLC6A2 P23975 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37
HTT P42858 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
TSHR P16473 1/20 0.35
RECQL P46063 2/20 0.35
ARG1 P05089 1/20 0.35
ARG2 P78540 1/20 0.35
MMP8 P22894 1/20 0.35
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA7 P43166 1/20 0.34
CA14 Q9ULX7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7440502 0.88 SMN1; SMN2 (0.45) ALDH1A1CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL27420773 0.81 ALDH1A1 (0.46) MAPTALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL9555264 0.80 SMN1; SMN2 (0.45) MAPTALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL12583561 0.77 SMN1; SMN2 (0.47) MAPTALDH1A1CYP3A4CYP2C9CYP2C19
SCHEMBL4396692 0.76 SMN1; SMN2 (0.55) ALDH1A1CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL4396691 0.76 SMN1; SMN2 (0.55) ALDH1A1CYP3A4CYP2C9CYP2C19HIF1A
Hydrochloric Acid SCHEMBL4398174 0.75 SMN1; SMN2 (0.53) ALDH1A1CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL9551389 0.75 HTT (0.54) MAPTALDH1A1CYP3A4CYP2C9CYP2C19
Hydrochloric Acid SCHEMBL4398176 0.75 SMN1; SMN2 (0.53) ALDH1A1CYP3A4CYP2C9CYP2C19HIF1A
SCHEMBL9551388 0.75 HTT (0.54) MAPTALDH1A1CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1053246-B1 BETA-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF MOLECUMETICS LTD (US) 2003-01-02 EP disclosed
EP-1053246-A1 BETA-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF MOLECUMETICS, LTD. (US) 2000-11-22 EP disclosed
US-6020331-A β-sheet mimetics and use thereof as protease inhibitors MOLECUMETICS, LTD. (US) 2000-02-01 US disclosed
WO-1999041276-A1 β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF MOLECUMETICS LTD. (US) 1999-08-19 WO disclosed
EP-0915700-A1 USE OF BETA-SHEET MIMETICS AS PROTEASE AND KINASE INHIBITORS AND AS INHIBITORS OF TRANSCRIPTION FACTORS MOLECUMETICS, LTD. (US) 1999-05-19 EP disclosed
WO-1998005333-A1 USE OF BETA-SHEET MIMETICS AS PROTEASE AND KINASE INHIBITORS AND AS INHIBITORS OF TRANSCRIPTION FACTORS MOLECUMETICS LTD. (US) 1998-02-12 WO disclosed