Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002972 | 0.85 | HPGD (0.36) | LRRK2GABRG2GABRB3GABRA5 | |
| SCHEMBL7002461 | 0.84 | GABRA1 (0.33) | LRRK2GABRG2GABRB3GABRA5 | |
| SCHEMBL7003645 | 0.83 | LRRK2 (0.32) | LRRK2GABRG2GABRB3GABRA5 | |
| SCHEMBL7002883 | 0.81 | GABRA1 (0.32) | LRRK2GABRG2GABRB3GABRA5 | |
| SCHEMBL7001199 | 0.69 | HPGD (0.36) | LRRK2GABRG2GABRB3GABRA5 | |
| SCHEMBL7002447 | 0.66 | GABRA1 (0.35) | LRRK2GABRG2GABRB3GABRA5 | |
| SCHEMBL2657456 | 0.64 | GABRA1 (0.37) | LRRK2GABRG2GABRB3GABRA5 | |
| SCHEMBL6995318 | 0.64 | GABRG2 (0.33) | GABRG2GABRB3GABRA5 | |
| SCHEMBL7005019 | 0.63 | GABRA1 (0.34) | GABRG2GABRB3GABRA5 | |
| SCHEMBL7003232 | 0.62 | GABRA1 (0.34) | GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |