Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | DCTPP1 | Q9H773 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001541 | 0.85 | LRRK2 (0.32) | GABRG2GABRB3GABRA5LRRK2 | |
| SCHEMBL7001199 | 0.83 | HPGD (0.36) | HPGDHSD17B10CREBBPDCTPP1MAPT | |
| SCHEMBL7002461 | 0.69 | GABRA1 (0.33) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7003645 | 0.69 | LRRK2 (0.32) | GABRG2GABRB3GABRA5LRRK2 | |
| SCHEMBL6995318 | 0.66 | GABRG2 (0.33) | MAPTTYK2GABRG2GABRB3GABRA5 | |
| SCHEMBL7002883 | 0.66 | GABRA1 (0.32) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7002447 | 0.66 | GABRA1 (0.35) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL2658702 | 0.66 | GABRA1 (0.44) | HPGDHSD17B10ALDH1A1GABRG2GABRB3 | |
| SCHEMBL7484271 | 0.65 | GABRA1 (0.52) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7207868 | 0.65 | GABRA1 (0.45) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1107967-B1 | TRIAZOLOPYRIDAZINE DERIVATIVES FOR ENHANCING COGNITION | MERCK SHARP & DOHME (GB) | 2003-05-14 | — | — | EP | claimed |