Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2958457 | 0.93 | GPR119 (0.48) | GPR119CHRNB2CHRNA4HDAC1PARP1 | |
| SCHEMBL2955018 | 0.90 | GPR119 (0.46) | GPR119CHRNB2CHRNA4HDAC1PARP1 | |
| SCHEMBL2949364 | 0.86 | GPR119 (0.48) | GPR119CHRNB2CHRNA4HDAC1PARP1 | |
| SCHEMBL11963191 | 0.86 | GPR119 (0.48) | GPR119CHRNB2CHRNA4HDAC1PARP1 | |
| SCHEMBL3050128 | 0.86 | GPR119 (0.47) | GPR119HDAC1PARP1HSD11B1RET | |
| SCHEMBL3050124 | 0.86 | GPR119 (0.47) | GPR119HDAC1PARP1HSD11B1RET | |
| SCHEMBL23042937 | 0.85 | GPR119 (0.51) | GPR119HDAC1PARP1HSD11B1RET | |
| SCHEMBL5036684 | 0.85 | CHRNB2 (0.57) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL30261886 | 0.85 | GPR119 (0.51) | GPR119HDAC1PARP1HSD11B1RET | |
| SCHEMBL7145919 | 0.83 | CHRNB2 (0.52) | GPR119CHRNB2CHRNA4HDAC1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147112-B1 | DIAZABICYCLIC DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | ABBOTT LAB (US) | 2003-10-29 | — | — | EP | disclosed |