Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 14/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6013380 | 0.90 | TNF (0.60) | TNFDPP4KDM4E | |
| SCHEMBL7005492 | 0.86 | PDE4A (0.46) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7001995 | 0.74 | DPP4 (0.41) | PDE4APDE4BPDE4CPDE4DDPP4 | |
| SCHEMBL7004334 | 0.74 | DPP4 (0.55) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL11210331 | 0.73 | TNF (0.58) | TNFGAAALDH1A1 | |
| SCHEMBL6384593 | 0.73 | TNF (1.00) | TNFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4251174 | 0.69 | TNF (0.56) | TNF | |
| SCHEMBL835698 | 0.69 | TNF (0.58) | TNFADORA2AADORA2B | |
| SCHEMBL13144469 | 0.68 | TNF (0.47) | TNFGAAALDH1A1HPGDHSD17B10 | |
| SCHEMBL8437638 | 0.68 | PNP (0.44) | TNFGAAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187838-B1 | Thiazolopyrimidines useful as TNF-Alpha inhibitors | UNIV CALIFORNIA (US) | 2003-08-06 | — | — | EP | claimed |