Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 15/20 | 0.60 |
| ▸ | DPP4 | P27487 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001999 | 0.90 | TNF (0.61) | TNFDPP4KDM4E | |
| SCHEMBL7004334 | 0.84 | DPP4 (0.55) | TNFDPP4 | |
| SCHEMBL7005492 | 0.75 | PDE4A (0.46) | TNFDPP4 | |
| SCHEMBL5424162 | 0.72 | TNF (1.00) | TNF | |
| SCHEMBL9412588 | 0.72 | TNF (0.57) | TNF | |
| SCHEMBL11210331 | 0.71 | TNF (0.58) | TNF | |
| SCHEMBL7164129 | 0.69 | TNF (1.00) | TNFKDM4E | |
| SCHEMBL17682312 | 0.69 | TNF (1.00) | TNF | |
| SCHEMBL13144469 | 0.69 | TNF (0.47) | TNF | |
| SCHEMBL9412660 | 0.68 | TNF (0.53) | TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187838-B1 | Thiazolopyrimidines useful as TNF-Alpha inhibitors | UNIV CALIFORNIA (US) | 2003-08-06 | — | — | EP | claimed |
| US-7098216-B2 | Thiazolopyrimidines useful as TNFα inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-08-29 | — | — | US | disclosed |
| US-6930101-B1 | Thiazolopyrimidines useful as TNFα inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-08-16 | — | — | US | disclosed |
| US-20050065116-A1 | Thiazolopyrimidines useful as TNFalpha inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-03-24 | — | — | US | disclosed |
| EP-1187838-B1 | Thiazolopyrimidines useful as TNF-Alpha inhibitors | UNIV CALIFORNIA (US) | 2003-08-06 | — | — | EP | disclosed |
| EP-1187838-A1 | THIAZOLOPYRIMIDINES USEFUL AS TNF-ALPHA INHIBITORS | The Regents of the University of California (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000069861-A1 | THIAZOLOPYRIMIDINES USEFUL AS TNFα INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065116-A1 | Thiazolopyrimidines useful as TNFalpha inhibitors | TNF, TNFRSF1A, TNFRSF9 | TNF 1/4885DPP4 222/4885KDM4E 3811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.