Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.55 |
| ▸ | TNF | P01375 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7005492 | 0.88 | PDE4A (0.46) | DPP4TNFADORA2BPDE4APDE4B | |
| SCHEMBL6013380 | 0.84 | TNF (0.60) | DPP4TNF | |
| SCHEMBL6880028 | 0.72 | TNF (0.56) | TNFCYP1A2ALDH1A1CYP2C19LMNA | |
| SCHEMBL18460236 | 0.71 | TNF (0.52) | TNFCYP1A2ALDH1A1CYP2C19LMNA | |
| SCHEMBL1729797 | 0.70 | FABP4 (0.44) | CYP1A2LMNATSHRNFKB1PMP22 | |
| SCHEMBL11293447 | 0.70 | PDE4A (0.71) | ADORA2BPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5688391 | 0.70 | CYP1A2 (0.55) | TNFCYP1A2ALDH1A1CYP2C19LMNA | |
| SCHEMBL3771053 | 0.69 | FABP4 (0.46) | CYP1A2ALDH1A1CYP2C19LMNA | |
| SCHEMBL30976974 | 0.69 | APEX1 (0.47) | CYP1A2LMNASMN1; SMN2 | |
| 1-[4-Carboxypropyl]-3,7-Dimethylxanthine SCHEMBL5420399 | 0.68 | ADORA2B (0.74) | TNFCYP1A2LMNAADORA2BUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187838-B1 | Thiazolopyrimidines useful as TNF-Alpha inhibitors | UNIV CALIFORNIA (US) | 2003-08-06 | — | — | EP | claimed |