Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK10 | O94804 | 7/20 | 0.33 |
| ▸ | SLK | Q9H2G2 | 7/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7000064 | 0.88 | PGR (0.35) | PDE3BPDE3ABRAFHSD11B1 | |
| SCHEMBL6995597 | 0.85 | PGR (0.38) | STK10SLKARBRAF | |
| SCHEMBL6997346 | 0.84 | PTGS2 (0.32) | — | |
| SCHEMBL6998749 | 0.83 | TP53 (0.33) | AKR1C3AKR1C2 | |
| SCHEMBL6994262 | 0.82 | KIF11 (0.37) | STK10SLKPDE3BPDE3ATRPA1 | |
| SCHEMBL6999902 | 0.82 | PGR (0.34) | AKR1C3AKR1C2 | |
| SCHEMBL6999446 | 0.82 | PTGS2 (0.37) | STK10SLKALOX5APFEN1PDE3B | |
| SCHEMBL6997543 | 0.82 | PTGS2 (0.37) | — | |
| SCHEMBL6998821 | 0.81 | STK10 (0.42) | STK10SLKAKR1C3AKR1C2ALOX5AP | |
| SCHEMBL6996435 | 0.81 | BRAF (0.35) | PDE3BPDE3ABRAFHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | claimed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | claimed |
| EP-1109799-B1 | 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS | PACIFIC CORP (KR) | 2003-12-17 | — | — | EP | disclosed |
| US-6492416-B1 | TREATING INFLAMMATION AND ASSOCIATED DISORDERS | PACIFIC CORPORATION (KR) | 2002-12-10 | — | — | US | disclosed |