Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PARG | Q86W56 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7526733 | 0.92 | PIK3R1 (0.42) | L3MBTL1HRH4MAPTLMNACYP3A4 | |
| SCHEMBL6853905 | 0.91 | L3MBTL1 (0.47) | L3MBTL1MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL6855837 | 0.90 | PIK3R1 (0.44) | L3MBTL1MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL6854824 | 0.90 | PIK3R1 (0.44) | L3MBTL1MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL6855251 | 0.89 | MAPT (0.38) | L3MBTL1MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL6850124 | 0.89 | MAPT (0.46) | L3MBTL1MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL6854981 | 0.89 | PIK3R1 (0.45) | L3MBTL1MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL6849937 | 0.89 | TP53 (0.39) | L3MBTL1MAPTALDH1A1KDM4EHTT | |
| SCHEMBL6854500 | 0.87 | L3MBTL1 (0.46) | L3MBTL1MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL6855322 | 0.87 | ALDH1A1 (0.48) | L3MBTL1HRH4MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | claimed |
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | disclosed |
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | disclosed |